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Other weaknesses are that it has not been decided In the event the statistically most precise system for combining final results is definitely the fastened, IVhet, random or high quality effect designs, although the criticism in opposition to the random consequences product is mounting due to the notion the new random outcomes (Utilized in meta-ana

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One example is, if a examination has an NPV of seventy five%, Which means that 75% with the individuals that test detrimental are definitely condition absolutely free, when twenty five% who examination destructive hold the ailment (Phony negatives). The NPV for just a exam differs depending on how widespread the illness is while in the populace cur

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